Rafael Nadal and Roger Federer eased through as Novak Djokovic departed on a day of upsets at the Indian Wells Masters.
Nadal and Federer were untroubled in comfortable third-round wins over Diego Schwartzman and Stan Wawrinka respectively on Tuesday.
But Djokovic, who shares the record for most titles at the ATP 1000 event with five alongside Federer, was stunned by Philipp Kohlschreiber.
The world number one was joined by Kei Nishikori and Marin Cilic in suffering a shock loss.
NADAL PERFECT AGAINST SCHWARTZMAN
Nadal improved to 7-0 against Diego Schwartzman courtesy of a 6-3 6-1 thrashing.
The Spaniard is a three-time champion at Indian Wells, but the last of those titles came in 2013.
Nadal will next face Filip Krajinovic, who crushed 14th seed Daniil Medvedev 6-3 6-2.
No sweat @RafaelNadal improves his record to 7-0 lifetime against Diego Schwartzman with a 6-3, 6-1 win to punch into the fourth round.#BNPPO19 pic.twitter.com/XNWSLQA62f— BNP Paribas Open (@BNPPARIBASOPEN) March 12, 2019
Federer continued his dominance over Wawrinka with a straightforward 6-3 6-4 victory.
The 20-time grand slam champion made it 22 wins in 25 clashes against Wawrinka, who was below his best in a loss in under an hour.
Federer’s last-16 opponent is Kyle Edmund, the Brit cruising past Radu Albot 6-3 6-3.
Poetry in Motion@rogerfederer improves to 17-0 on hard courts against Stan Wawrinka with a 6-3, 6-4 dismantling to fly into the fourth round.#BNPPO19 pic.twitter.com/M7qBX7b8z2— BNP Paribas Open (@BNPPARIBASOPEN) March 13, 2019
DJOKOVIC DEPARTS AS SEEDS FALL
In a clash pushed back due to rain, Djokovic went down to German veteran Kohlschreiber 6-4 6-4.
Djokovic had won eight of his previous nine clashes against Kohlschreiber, who claimed his first victory over the Serbian since 2009.
35-year-old @Kohlscribbler collects his first win over Novak Djokovic since 2009 @rolandgarros with a gutsy 6-4, 6-4 performance. He faces Gael Monfils next in the fourth round.#BNPPO19pic.twitter.com/M4JCOLGcoX— BNP Paribas Open (@BNPPARIBASOPEN) March 12, 2019
Elsewhere, Hubert Hurkacz upset Nishikori 4-6 6-4 6-3 to set up a meeting with Denis Shapovalov.
Cilic, the Croatian 10th seed, was no match for Shapovalov in a 6-4 6-2 defeat.
John Isner and Karen Khachanov secured wins to set up a fourth-round clash.