Enyimba International will begin their CAF Confederation Cup quest against Benin Republic side Energie FC while Akwa United have been paired against Al-Ittihad of Libya.
This is the first time since 2012 that all four NPFL teams would avoid been knocked out from the first round of the qualifiers. The next round of matches will come up next month.
Plateau United who defeated their opponents home and away will tackle Etoile Sportif Du Sahel (Tunisia) and MFM FC who scrape through against Real Bamako of Mali will face MC Algeirs (Algeria).
CAF Champions League
Plateau Utd vs Etoile Sportif Du Sahel (Tunisia)
MFM FC vs MC Algeirs (Algeria)
CAF Confederations Cup
Akwa United vs Al-Ittihad (Libya)
Enyimba vs Energie (Benin Republic)